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Sekundær binyrebarkinsufficiens under opioidbehandling

Ved sekundær binyrebarkinsufficiens bør der foretages MR-skanning for at udelukke patologi i hypofyse og hypothalamus.
Forfatter(e)
Jonatan Kornholt Geriatrisk Afdeling, Bispebjerg Hospital Ugeskr Læger 2016;178:V12150948
Reference: 
Ugeskr Læger 2016;178:V12150948
Blad nummer: 
Sidetal: 
2-3
Secondary adrenal insufficiency during opiate treatment
A 25-year-old previously healthy man developed secondary adrenal insufficiency during opiate treatment with tramadol and morphine for upper back pain. He experienced a 10 kg weight loss in six weeks. MRI of the hypothalamus and the pituitary gland ruled out cerebral pathology. After dis­con­tinuation of the opiate treatment the condition normalised. Opiate therapy can cause endocrine dysfunction, and clinicians should always consider adverse drug reactions as a differential diagnosis for unexplained symptoms.
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