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Stevens Johnsons syndrom og toksisk epidermal nekrolyse

Patient med toksisk epidermal nekrolyse.
Diljit Kaur-Knudsen, Claus Zachariae & Simon Francis Thomsen Hud- og allergiafdelingen, Gentofte Hospital
Ugeskr Læger 2013;175
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Stevens-Johnson syndrome and toxic epidermal necrolysis
Stevens-Johnson syndrome and toxic epidermal necrolysis are acute mucocutaneous diseases primarily due to drug intake. The diseases are characterised by the separation of epidermis from dermis which can be life-threatening. Mortality is often caused by sepsis and multiple organ failure. The most common drugs involved are antibiotics, antiepileptic medicine, allopurinol and nonsteroidal anti-inflammatory drugs. Besides withdrawing the suspected drug the treatment is mainly symptomatic. A number of systemic treatments have been suggested including systemic corticosteroids, intravenous immunoglobulins, cyclosporine, granulocyte colony stimulating factor and tumour necrosis factor-alpha inhibitors although they remain controversial.
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