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Succesfuld behandling af KCNJ11-neonatal diabetes uden insulin

Forfatter(e)
Birthe Gade-Rasmussen1, Sten Madsbad1, Maria Saur Svane1, Christoffer Martinussen1 & Torben Hansen2 1) Endokrinologisk Afdeling,
Hvidovre Hospital2) Novonordisk Foundation Center for Basic Metabolic Research,
Københavns Universitet

Ugeskr Læger 2018;180:V08180547
Reference: 
Ugeskr Læger 2018;180:V08180547
Blad nummer: 

Birthe Gade-Rasmussen, Sten Madsbad, Maria Saur Svane, Christoffer Martinussen & Torben Hansen:

Successful treatment of KCNJ11 neonatal diabetes without insulin

Ugeskr Læger 2018;180:V08180547

In this case report a 40-year-old insulin-treated male patient presented with a KCNJ11 R201H mutation, which can cause neonatal diabetes. After initiation of treatment with high doses of the sulfonylurea glibencamide in combination with the glucagon-like peptide 1 receptor agonist liraglutide, insulin treatment of the patient could be terminated. The first nine months after termination of insulin treatment the glycated haemoglobin concentration was 48-54 mmol/mol (i.e. 6.5-7.1%).

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