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Tab af X-kromosomet kan være et aldersbetinget fænomen hos kvinder


Anne Marie Jelsig, Karen Brøndum-Nielsen & Asuram Zeynep Tümer

Klinisk Genetisk Klinik, Kennedy Centret, Rigshospitalet Ugeskr Læger 2018;180:V10170731

Ugeskr Læger 2018;180:V10170731
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X-chromosome loss can be an age-related phenomenon in women

During chromosome analysis the finding of few cells with X-chromosome aneuploidy in a phenotypically normal woman is not unusual – so-called low-grade mosaicism for X aneuploidy (LLX-A). Such results can be difficult to interpret. In this review, LLX-A and its clinical implications are discussed, and based on the current literature it can be concluded, that LLX-A is an age-related phenomenon not related to reproductive issues such as recurrent abortions. This should be taken into account in any laboratory performing chromosome analysis.

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