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Terapeutisk stofmåling af β-laktamantibiotika

Forfatter(e)

Nima Tanha1, Lise Bathum2, Jens Kristian Munk2, Niels Frimodt-Møller3, Christian Østergaard Andersen4 & Thomas Benfield1, 5

1) Afdeling for Infektionssygdomme, Amager Hvidovre Hospital, 2) Institut for Klinisk Biokemi, Amager Hvidovre Hospital, 3) Klinisk Mikrobiologisk Afdeling, Rigshospitalet, 4) Klinisk Mikrobiologisk Afdeling, Amager Hvidovre Hospital, 5) Institut for Klinisk Medicin, Det Sundhedsvidenskabelige Fakultet, Københavns Universitet,
Ugeskr Læger 2020;182:V01200066

Reference: 
UgeskrLæger 2020;182:V01200066
Therapeutic drug monitoring of β-lactam antibiotics

Nima Tanha, Lise Bathum, Jens Kristian Munk, Niels Frimodt-Møller, Christian Østergaard Andersen & Thomas Benfield

Ugeskr Læger 2020;182:V01200066

Traditional β-lactam antibiotic dosing does not consider physiological changes in medical conditions such as sepsis. Optimal antibiotic exposure could be achieved by therapeutic drug monitoring (TDM). This review gives a brief summary. Current studies are sparse, but suggestive of a potential beneficial role of TDM to patients with reduced renal function, obese patients and the critically ill. TDM can potentially reduce adverse effects and optimise antibiotic exposure. However, standardised TDM methods are lacking and randomised clinical studies are warranted in order to prove clinical benefit.

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