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Toksisk shock-syndrom

Forfatter(e)

Niklas Schurmann Hansen1, Steffen Leth2 & Lars Toft Nielsen2

1) Anæstesiologisk Afdeling, Sygehus Lillebælt, 2) Infektionsmedicinsk Afdeling, Aarhus Universitetshospital

Ugeskr Læger 2020;182:V11190673

Reference: 
Ugeskr Læger 2020;182:V11190673
Blad nummer: 
Toxic shock syndrome

Niklas Schurmann Hansen, Steffen Leth & Lars Toft Nielsen:

Ugeskr Læger 2020;182:V11190673

Toxic shock syndrome is a rare, life-threatening disease caused by Staphylococcus aureus or Streptococcus pyogenes. These bacteria are able to produce superantigens, which bypass normal antigen presentation and cause a clonal T-cell expansion and uncontrolled release of pro-inflammatory mediators, which results in severe multiple organ failure. Despite high morbidity and mortality, the disease is underdiagnosed. In order to reduce morbidity and mortality early diagnosis and treatment with a combination of beta-lactam antibiotics, clindamycin and intravenous immunoglobulin is essential, which is underlined in this review.

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