Nanna Himmelstrup, Cecilie Helkjær Engen, Lars Østergaard & Thomas Lars Benfield:
Vaccination for meningococcal disease
Ugeskr Læger 2019;181:V09180611
Neisseria meningiditis is a cause of sepsis and meningitis. Based on the capsule, six groups are recognised to cause invasive disease: A, B, C, W135, X and Y. In Denmark, five vaccines are marketed to protect against five of the six groups. One conjugated glycoprotein vaccine against serogroup C alone: MenC, two conjugated vaccines against ACWY: ACWY-TT/ACWY-CRM, and two protein-based vaccines against serogroup B: 4CMenB and MenB-fHbp. Overall, the efficacy is good, but the persistence of immunity is decreasing over time, why a booster is recommended for long-term protection.