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Voriconazolinduceret periostitis

Forfatter(e)
Ditte Marie Jakobsen1, Bjarte Aspenes Justad2, Jannik Helweg-Larsen1 & Terese Lea Katzenstein1
1) Infektionsmedicinsk Klinik, Rigshospitalet. 2) Klinik for Klinisk Fysiologi, Nuklearmedicin og PET, Rigshospitalet

Ugeskr Læger 2019;181:V12180870

Reference: 
Ugeskr Læger 2019;181:V12180870
Blad nummer: 

Ditte Marie Jakobsen, Bjarte Aspenes Justad,
Jannik Helweg-Larsen & Terese Lea Katzenstein:

Voriconazole-induced periostitis

Ugeskr Læger 2019;181:V12180870

In this case report, a 49-year-old man was diagnosed with influenza-associated invasive aspergillosis. Voriconazole therapy was initiated and adjusted to meet therapeutic range. After 16 weeks of treatment the patient was admitted with multifocal, skeletal pains. Alkaline phosphatase was 1,900 U/L and S-voriconazole 9.9 mg/l. A bone scintigraphy and SPECT-CT were performed, and the diagnostic images along with the clinical findings were consistent with voriconazole-induced periostitis. Voriconazole therapy was discontinued, and isavuconazole therapy was initiated, and the patient’s symptoms resolved completely.

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